Director, Downstream Process Development and Manufacturing

Full time position

Company Summary

Axovant develops transformative gene therapies for patients with life-altering neurologic conditions.


Our mission is to identify, develop, and bring to market high-impact therapies that have the potential to improve the lives of patients with neurological disorders. Our team is made up of leading scientific experts who are passionate about treating neurological conditions and easing the burden of these life-changing disorders for both patients and caregivers. Our team is motivated by the promise of novel drug development and is driven to find more efficient and effective ways to conduct scientific and clinical evaluations that rapidly deliver impactful medicines to patients in need.


Our leadership team has a track record bringing innovative new neurotherapeutic treatments to a global market, and along with our seasoned board of directors, is fully committed to the responsible pursuit of transformative therapies for some of the world's most difficult conditions.


Overall Summary


Axovant is seeking a highly motivated Director, Downstream Process Development and Manufacturing, for Axovant’s AAV gene therapy programs. Reporting to the Vice President of Technical Operations, the Director, Downstream Process Development and Manufacturing, will be responsible for the development and improvement of the downstream process of viral gene therapy vectors, as well as for the oversight of the tech transfer to and implementation at contract organizations.

Primary Responsibilities
  • Development of downstream process strategies for viral gene therapy vectors.

  • Identification and selection of contract development organizations for performing the development and improvements of downstream processes for viral gene therapy vectors.

  • Responsibility for the execution of the downstream process development at contract laboratories.

  • Oversight of technical transfer to contract manufacturing organizations, as well as proper implementation of the downstream process at the manufacturing site.

  • Coordination with internal and external parties, including Program Management, Upstream Process Development, Manufacturing, Analytics and Supply chain.

  • Identification and communication of risks in the downstream process and their mitigation.

  • Responsibility to develop, author, review, and/or approve Standard Operating Procedures, specifications, regulatory filings, or other controlled documents, as needed.

  • Representation of the company as downstream process expert

  • M.S or equivalent in Chemistry, Biological Sciences, Engineering or related discipline, with 12+ years of experience; Ph.D. with 9+ years of experience preferred.

  • Knowledge in interacting efficiently with Upstream Process Development, Analytics, and Quality Assurance.

  • Expertise in early development as well as late stage/commercial pharmaceutical projects, preferably in gene therapy.

  • Occasional travel to contract organizations required.

  • Experience managing contract organizations.

  • Excellent written and verbal communication skills, good interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators).

  • Results oriented, has a bias for action. Strong initiative, accountability and willingness to take ownership and drive projects to completion.

  • Accustomed “roll up their sleeves” and execute the tasks needed in a small company environment.

  • Ability to set priorities, work independently and deliver results in a timely manner. Display a sense of urgency.


This is an exciting time to join the field of gene therapy in general, and to become a part of Axovant Gene Therapies’ fast-growing dedicated team. Axovant Gene Therapies is a publicly traded company (NASDAQ: AXGT). We offer an exciting, meaningful and collaborative fast-paced environment with a foundation of sound and rigorous science. Competitive compensation and benefits package can be expected.

All interested applicants should send a cover letter and resume to:



We maintain a list of approved professional recruiting agencies with which we have signed agreements. Candidates will be considered only when the agency has a signed agreement and Human Resources authorization to present candidates for a specified position(s). Candidates submitted outside of this process are considered unsolicited and will not be considered. Agencies interested in establishing a relationship with Axovant may send company information to A member of the Human Resources team will contact you if we require the services your company offers.


Eleven Times Square, 33rd Floor
New York, NY 10036
United States

+1-833-AXOVANT (1-833-296-8268)

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Viaduktstrasse 8
4051 Basel